MOTS-c
MOTS-c is a mitochondrial-encoded peptide that inhibits the methionine-folate cycle and increases PGC-1alpha. It has been shown to enhance metabolic homeostasis and reduce obesity and insulin resistance. It has also been used to enhance sports performance, and certain long-lived Japanese populations have demonstrated a phenotypic expression and biologic link between MOTS-c and an extended lifespan.